Hayward RA, Kent DM, Vijan S, Hofer TP.
Reporting clinical trial results to inform providers, payers, and consumers.
Health Affairs (Millwood). 2005 Nov-Dec;24(6):1571-81.
This article gives a candid account of how the "the conventional approach
to reporting clinical trials has fundamental flaws that can
result in overlooking identifiable subgroups harmed by a treatment
while underestimating benefits to others."
The reporting of some clinical studies can be biased in a number of ways: the perception of the researchers; and professional, political, and financial incentives. This report discusses the bias of "the desire to promote a beneficial treatment for use in
as many people as possible".
The authors recommend that the evidence reported in the study can be greatly enhanced by ensuring that "whenever a multivariable
prediction tool is available, the observed relative and absolute
risk reduction for subjects with higher versus lower predicted
net benefit should be reported using risk-stratified analysis.
This discussion is a reminder that all research that reports clinical trials should be carefully analyzed for accuracy.